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The aims of cancer immunotherapy is to empower patients immune system T cells to recognize and attack cancer.
Tumors used several methods to fight back immune system attack, like producing blood vessels that hinder arrival of T cells.
Scientists are now reprogramming the tumor blood vessels to treat different types of cancers.
Tumor blood vessels provide oxygen and nutrients to the growing cancer cells, scientists used AZV to block the actions of two proteins: VEGFA and ANGPTZ to starve the tumor.
AzV regress and normalized the tumor blood vessels and facilitated the arrival of activated T cells.
Anti-angiogenic drugs like ANGPTZ inhibitors have strong effect on tumor and initiative anti-tumor immune responses.