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Pseudomonas aeruginosa bacterium is a fatal threat to sick patients. Using two different types of antibiotics can reduce its effect on sick patients.
The combination treatment against Pseudomonas aeruginosa was effective in all age groups and for different infections.
Pseudomonas aeruginosa is a common bacterium, found in our environments. Some bacterial strains have become resistant to all antibiotics available.
Sick patients have a high risk of developing an infection caused by this bacterium.
Some of these patients develop sepsis-blood poisoning which can be deadly.
Bacterial vesicles is a type of excreted nanoparticles, which are dislodged from the bacterial surface.
Pseudomonas aeruginosa, like Moraxella catarrhalis bacterium, produces beta-lactamase that breaks down antibiotics. The bacteria use their vesicles to spread the substance.
The vesicles enable these and other bacteria to effectively colonise the body: when the vesicles spread, the body responds by engaging its immune system.
The vesicles protect their interior cargo and inhibit the immune system’s ability to neutralise the beta-lactamase, promoting bacterial invasion in the body.
Pseudomonas aeruginosa uses its vesicles was studied with particular focus on infection in the lungs. In this case, the vesicles trigger an increased production of vitronectin — a protective protein that controls the body’s immune system.
The Pseudomonas bacteria binds vitronectin to its surface and the immune response is subsequently stopped.