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Scientists have discovered how damage to the cell’s genetic material can trigger inflammation. Cancerous cells are similar to other cells at early stage, so that they can be removed as part of the body’s natural surveillance systems before tumours form.
A key molecule called cGAS is known to bind DNA, triggering inflammation.
When damage occurs, fragments of DNA can get separated from the nucleus and form structures micronuclei.
cGAS can penetrate these micronuclei and bind to DNA, creating mechanisms that lead to inflammation. DNA damage is one of the early steps in the development of cancer.
Detection of micronuclei by cGAS could be an important early signal to the human body to detect and remove potentially cancerous cells.
Autoinflammatory diseases- when the immune system attacks the body’s own tissues can also be an early sign of cancer, this could trigger an inflammatory diseases.
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