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How long we will live is encoded in our genome. Researchers have identified 16 genetic markers associated with a short lifespan. This reveals computational framework to uncover the genetics of our time of death and disease. It explained why some people live longer than others.
About 30 percent of the variation in human lifespan comes down to our genome. Changes in particular locations in our DNA sequence, such as single-nucleotide polymorphisms (SNPs), could be responsible for some of the reasons for our longevity.
Changes in the DNA is linked to age-related diseases. About 1 in 10 people carry some configurations of these markers that shorten their life by over a year compared with the population average. Those who inherited a lifespan-shortening version of one of these SNPs may die earlier than their mate.
The researchers explore how the DNA changes affected lifespan in a holistic way. They discovered that most SNPs had an effect on lifespan by impacting more than a single disease or risk factor, for example through being more addicted to smoking as well as through being predisposed to schizophrenia.
The discovered SNPs and gene expression data, allowed the researchers to identify that lower brain expression of three genes neighbouring the SNPs- RBM6, SULT1A1 and CHRNA5, involved in nicotine dependence was linked to increased lifespan. These three genes could therefore act as biomarkers for surviving beyond 100 years.