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Polycythemia Vera PV, is a blood cancer that causes an excess production of red blood cells. Common symptoms of PV are: itching, headache, weight loss, fatigue and night sweats.
Researchers have discovered that methotrexate MTX- a drug for treatment of arthritis can be useful for treating blood cancer.
The drug works by directly inhibiting the molecular pathway causing the disease. Blood cancer could be treated with methotrexate MTX an arthritis drug.
Methotrexate acts as a potent suppressor in cells carrying the mutated gene responsible for myeloproliferative neoplasms MPNs in patients.
Low-dose of MTX suppresses JAnus kinase JAK/STAT Signal Transducer and Activation of Transcription pathway activity and is able to normalise the raised blood counts and the increase in spleen size associated with blood cancer.
Methotrexate MTX has the potential to provide a new molecularly targeted treatment for myeloproliferative neoplasms patients MNP
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