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Increasing lactate production genetically increases the stem cells in dormant hair follicles to grow again.
Receding hairlines and thinning crowns can be caused by aging, genetics, hormone imbalance, stress, illness and medications. The metabolic process that takes place in hair follicle stem cells is different from that which takes place in other skin cells.
Cells convert glucose into pyruvate but this metabolite can take one of two paths; it can be sent to the mitochondria and used as energy, or the cells can convert it to a different metabolite known as lactate – the same substance produced during intense exercise that causes a burning sensation in muscles.
Changing the chemical course of the glucose metabolites could change the behavior of inactive follicles. Researchers examined mice that had been genetically engineered to not produce lactate along with those that had been altered to increase lactate production.
They discovered that blocking lactate prevented hair follicle stem cells from being activated while increasing lactate increased the production of hair. When the drugs – RCGD423 and UK5099 were applied to the skin of mice, both increased lactate production and
accelerate hair growth.
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