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Researchers have discovered that reduced function of a gene that impacts the breakdown of fats resulted in adult-onset obesity and fatty liver. In normal metabolism, fat and carbohydrate in our diets was broken down to produce the energy that our bodies required by the cellular energy plants, known as mitochondria.
Faulty mitochondrial gene had major impacts on normal metabolic function, if mitochondria are compromised or damaged, the breakdown of fat and carbohydrates will be poorly regulated, which can lead to adult-onset obesity.
Healthy adults will have two copies of the Pentatricopeptide repeat-containing protein 1, PTCD1 gene, PTCD1 is vital for the breakdown of fats, carbohydrates and energy production. When one copy of this gene is lost, it results in obesity, fatty liver and heart disease
PTCD1 affects the way mitochondria are formed by changing their shape and making them less connected with each other. Excess weight and obesity are major risk factors for diabetes, cardiovascular disease, musculoskeletal disease and cancers.
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