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Nonalcoholic fatty liver disease NAFL increases the risk of chronic liver diseases such as liver cirrhosis, liver cancer, type 2 diabetes and cardiovascular diseases. Altered secretion of the fatty liver increases production of glucose, fats, and proteins like hepatokine fetuin-A, which are releases into the bloodstream.
The secreted substances of the fatty liver enter other organs and trigger further reactions. People who had experienced an increased pancreatic fatty degeneration have reduced insulin secretion.
Fatty liver and fatty degeneration of the pancreas triggers increased local immune cell infiltration and inflammation that increase the disease.
However, adipose tissue is not harmful, it can even have protective effects: adipose tissue located around the blood vessels of the kidney has regenerative properties.
The factor that leads to pathological changes is fetuin-A, which is produced by the fatty liver, instead of protecting tissue as before, the adipose tissue brings out inflammatory processes that leads to a restriction of renal function.
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