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Reserchers have discovered an insidious new autoimmune disease that causes kidney failure. Anti-brush border antibody ABBA disease. Researchers identified ABBA after analyzing biopsied kidney tissue from different patients who had developed acute kidney injury, a sudden episode of kidney failure or damage that happens within a few hours or days.
The condition causes a build-up of waste products in the blood and makes it difficult for kidneys to maintain adequate balance of fluid in the body.
Researchers discovered that in the nephrons, the functional units of the kidneys, antibodies had coated a specialized part of cells called brush borders, which help reabsorb and process proteins.
Since it is an autoimmune disease, different approaches to suppress the immune system were used to treat the patients, but those efforts were unsuccessful, determining where on the protein megalin – which acts as a sponge to absorb proteins and other compounds that enter the nephron – the antibody binds is very important for key to treating the disease.
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