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Urea plays a role in the two-way link between the two diseases. Urea comes from the breakdown of protein in food. Kidneys normally remove urea from the blood, but poor kidney function can lead to increased levels of urea.
The study involved the analysis of medical records of adults who did not have diabetes. About 9 percent had elevated urea levels, a sign of reduced kidney function. That’s the same rate as in the general population, according to the researchers.
People with high urea levels were 23 percent more likely to develop diabetes than those with normal urea levels, the study found. Diabetes is a major risk factor for kidney disease, elevated levels of urea, also raises the risk of diabetes.
When urea builds up in the blood because of kidney dysfunction, increased insulin resistance and impaired insulin secretion often result.
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