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A study conducted before and after the 2004 closure of a coal-burning power plant in Tongliang, China, found children born before the closure had shorter telomeres than those conceived and born after the plant stopped polluting the air. Telomeres are specialized sections of DNA that allow chromosomes to be faithfully copied during cell division. However, with each round of cell division, telomeres shorten, resulting in a gradual loss of genomic stability. Shortened telomere length has been linked with cancer and heart disease, cognitive decline, aging, and premature death.
Led by Deliang Tang and Frederica Perera at Columbia University’s Mailman School of Public Health, the research team analyzed telomere length in the umbilical cord blood of 255 newborns, about half of whom were born before the plant closure and half conceived and born after. In babies born pre-closure, researchers found higher levels of PAH-DNA cord adducts, a biomarker for exposure to polycyclic aromatic hydrocarbons , a toxic component of air pollution from coal plants.
Elevated levels of these adducts in cord blood were associated with shorter telomeres-the first time this relationship has been tested as well as with lower levels of brain-derived neurotropic factor (BDNF), a protein involved in neuronal grown. However, telomere length was not associated with developmental score in the subset of 210 children tested at age 2, although the researchers say the finding doesn’t rule out telomere length-related neurodevelopmental problems at later ages.
Individual’s telomere length at birth is known to influence their risk for disease later during adulthood, high levels of air pollution in Tongliang prompted the government to shut down the local coal-burning power plant to improve community health. This action, announced in advance, provided a unique opportunity to compare data on ambient PAH levels, biomarkers, and health outcomes in two successive cohorts of children, with and without prenatal exposure to emissions from the coal-fired power plant.
In previously published research on these cohorts, the authors reported newborns born after the plant closure had lower levels of PAH-DNA adducts, lower rates of various health outcomes, and increased levels of BDNF. The new study adds to the evidence that closing this coal-burning power plant was beneficial to the health and future well-being of newborns there, reducing exposure to air pollution is recommended for pregnant women and infants.
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