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The nicotine in e-cigarettes seems to damage DNA in ways that may increase cancer risk, the damage was seen both to DNA and its ability to repair itself, making cells more likely to mutate and develop into cancer, said lead researcher Moon-shong Tang, a professor of environmental medicine at New York University School of Medicine.
Reseachers exposed laboratory mice to e-cigarette vapor, which contains both nicotine and liquid solvents. They also exposed mice to the nicotine and the solvents separately. The vapors were produced using 4.2 volts of electricity, at or below the level at which most commercial e-cigarettes function.
Prior studies have shown that e-liquid heated using higher levels of electricity could produce harmful chemicals. This research team wanted to investigate the risk posed to people using a typical e-cigarette. They found the solvent alone does not cause DNA damage, nicotine with e-cigarette solvent caused the same damage as nicotine alone. The researchers also exposed cultured human lung and bladder cells to nicotine, and found the same effects-DNA damage and suppressed DNA repair.
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