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According to Yale study, bacteria in the small intestines of mice and humans can go to other organs and cause an autoimmune response. The researchers also found that the autoimmune reaction can be suppressed with an antibiotic or vaccine designed to target the bacteria. Gut bacteria have been linked to a different diseases, including autoimmune conditions. Research team focused on Enterococcus gallinarum, a bacterium they discovered is able to spontaneously “translocate” outside of the gut to lymph nodes, the liver, and spleen.
In models of genetically susceptible mice, the researchers observed that in tissues outside the gut, E. gallinarum initiated the production of auto-antibodies and inflammation hallmarks of the autoimmune response. They confirmed the same mechanism of inflammation in cultured liver cells of healthy people, and the presence of this bacterium in livers of patients with autoimmune disease.
The research team discovered that they could suppress autoimmunity in mice with an antibiotic or a vaccine aimed at E. gallinarum. The researchers were able to suppress growth of the bacterium in the tissues and kill its effects on the immune system. The gut bacterium E. gallinarum moves from the gut to the liver and lymph nodes to stimulate liver and immune cells that leads to inflammation and autoimmune reactions. Liver inflammation leads to autoimmune hepatitis.
Autoantibodies generated systemically lead to lupus kidney disease and lupus-related autoimmune clotting called antiphospholipid syndrome. An oral antibiotic or a vaccine into the muscle that is directed against E. gallinarum prevent autoimmune diseases to occur.
Blocking the pathway leading to inflammation could reverse the effect of this bug on autoimmunity. The vaccine was delivered through injection in muscle to avoid targeting other bacteria that reside in the gut. Treatment with an antibiotic and vaccination ways of improving the lives of patients with autoimmune disease.
haleplushearty.org