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According to a scientific report, small, daily dose of Viagra reduces risk of colorectal cancer risk in an animal model. It reduces the formation of polyps, an abnormal and asymptomatic clump of cells on the lining of the intestines that may become cancer, says Dr. Darren D. Browning, cancer researcher at the Georgia Cancer Center and Department of Biochemistry and Molecular Biology at the Medical College of Georgia at Augusta University.
Viagra is used for treating premature infants with pulmonary hypertension and adult with erectile dysfunction. When placed in water, They discovered that Viagra reduced polyps in a mouse model with a genetic mutation that occurs in humans, causing them to produce hundreds of polyps starting as teenagers and resulting in colorectal cancer.
Viagra is known for its ability to relax the smooth muscle cells around blood vessels so the vessels can more easily fill with blood, which is how it helps both erectile dysfunction and pulmonary hypertension. But Browning’s lab is showing it also increases levels of the chemical cyclic GMP, which is known to affect the intestinal lining-epithelium.
Viagra suppresses excessive cell proliferation that occurs in the gut and an increase in normal cell differentiation as well as the natural elimination of abnormal cells by apoptosis. Proliferating cells are more subject to mutations that cause cancer. Existing polyps were not affected, more evidence that targeting cyclic GMP signaling appears to be a good prevention strategy in high-risk patients. Viagra inhibits PDE5- a natural occurring enzyme in colon cells and other tissues that breaks down cyclic GMP so there is more of it available to reduce cell proliferation and improve differentiation into cells like the goblet cells that secret protective mucus.
Guanylyl-cyclase C is the primary source of cyclic GMP in the intestinal lining. People with the genetic predisposition for polyps have reduced levels of GCC-activating peptides, which are also commonly lost in human colon cancers. The mice used for the experiment have mutations in the adenomatous polyposis coli APC – gene, a known tumor suppressor. People with mutations in the APC gene can develop hundreds of polyps in the colon and rectum and are considered at highest risk for colorectal cancer.
According to the National Institutes of Health, the average age of developing a colon cancer is 39, linaclotide used for treating constipation and irritable bowel syndrome increases cyclic GMP. Linaclotide is effective at reducing polyp formation but causes diarrhea after use. Viagra used by humans and in the lab have no side effect.
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