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Drugs used to treat major or minor illnesses may prevent the growth of bacteria in the human gut, these drugs cause antibiotic-like side-effects and may promote antibiotic resistance. Researchers screened different o drugs against bacteria from the human gut and found that some drugs of non-antibiotics affect the growth of at least one species in the microbiome.
The human gut contains a large number of species of bacteria-gut microbiome. Non-antibiotic drugs have been shown to cause changes in gut microbiome composition, change in the composition of gut bacteria contributes to drug side-effects. Intake of non-antibiotic drugs may promote antibiotic resistance, as the general resistance mechanisms of microbes to human-targeted drugs and to antibiotics seem to largely overlap.
Different people harbours a unique gut microbiome- different bacterial species – besides several common ones – and different individuals of the same species called strains. These strains can have different functions in the response to drugs. Therefore, many drug-microbe interactions are likely to be individual, opening paths for personalised drug therapies aimed at the individual gut microbiome.
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