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Collection of bacteria and other microbes in the gut could predict cirrhosis, according to Virginia Commonwealth University. Analysis of microbial DNA and microbial RNA could be used in clinical methods to predict cirrhosis. Microbial DNA analysis identifies live and dead bacterial species, while microbial RNA analysis identifies the most metabolically active microbial species.
Pathogenic and non-pathogenic bacteria in the gut microbiome would be accurate predictors of cirrhosis because of their link with inflammation, which often leads to infection. Researchers conducted a trial of patients with cirrhosis at VCU Medical Center and McGuire VA Medical Center who were classified according to cirrhosis-related complications, such as renal dysfunction and infection.
DNA and RNA analysis were equally effective at predicting hospitalization when combined with the standard predictive blood test. DNA and RNA analysis identified similar beneficial bacteria but differed in the pathogenic bacteria identified in all patient groups tested.
haleplushearty.org