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Researchers at the University of Washington have designed a convenient and natural product that uses proteins to rebuild tooth enamel and treat dental cavities. Remineralization guided by peptides is a healthy alternative to current dental health care. The new biogenic dental products can rebuild teeth and cure cavities without today’s uncomfortable treatments.
According to the World Health Organization, dental cavities affect every age group and are accompanied by serious health concerns. Bacteria metabolize sugar and other fermentable carbohydrates in oral environments and acid, as a by-product, will demineralize the dental enamel. Tooth decay is harmless in the earliest stages but when the cavity progresses through the tooth’s enamel, serious health concerns arise, which can leads to tooth loss.
Good oral hygiene is the solution, capturing the essence of amelogenin- a protein crucial to forming the hard crown enamel to design amelogenin-derived peptides that biomineralize and are the key active ingredient in the new technology. The bioinspired repair process restores the mineral structure found in native tooth enamel. These peptides are proven to bind onto tooth surfaces and recruit calcium and phosphate ions.
The peptide-enabled technology allows the deposition of 10 to 50 micrometers of new enamel on the teeth after each use. The technology can be used in private and public health settings, in biomimetic toothpaste, gels, solutions and composites as a safe alternative to existing dental procedures and treatments. It enables rebuild and strengthening of tooth enamel on a daily basis as part of a preventive dental care routine.
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