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Six small molecules from blood plasma were discovered in a group of college athletes who had been diagnosed with concussions. When these molecules were assessed, their combined presence accurately predicted whether teammates had sustained mild traumatic brain injury, mTBI or not. This suggests that these small molecules might be relevant biomarkers of mTBI.
The six biomarkers were tested in a separate group of participants with and without mTBI, and the results replicated the athlete findings. Although the results are encouraging, the authors report limitations to their study and recommend additional investigations related to these and other mTBI biomarkers in blood that will clarify their utility in clinical management.
The blood tests are important for detecting concussion and defining when injured individuals is eligible to return to regular activities. Diagnostic test might revolutionize the management of civilian and military concussions, including strategies to avoid post-concussive complications and more severe consequences, such as chronic traumatic encephalopathy. Researchers are workweek on advance technologies and therapeutic approaches that may benefit all societies.
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