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Scientists have identified a gene in women that is linked to the creation and location of new fat cells that contribute to the risk of type 2diabetes. Genetic variations that control KLF14 were associated with where in the body excess fat was stored. In women, versions of the gene that result in fat being stored around the hips and abdomen, were linked to a lower risk of diabetes.
The gene does not have an effect on overall weight but different variations of KLF14 were also related to the development and size of fat cells. Women with variations of the gene linked to the deposit of fat around the abdomen had fewer, larger fat cells which are less efficient. This means that the body’s sensitivity to insulin is decreased and therefore suggests that carriers of this variation of the gene are more at risk of diabetes.
The research also showed that the effects of these gene variations were specific to females. This variant of the KLF14 gene is thought to be one of the strongest known genetic risk factors for type 2 diabetes in females. Only the version of the gene inherited from an individual’s mother is active – the father’s version is silent. Women who inherited the risk version of the gene from their mother had around a 30 percent higher risk of diabetes than those without the risk version of the gene.
A natural variation of the gene KLF14 causes some women to store fat on their bellies and hips, this increases the risk of Type 2 diabetes, inheriting the gene from mother not father makes it dangerous. KLF14 is one of the strongest known genetic risk factors, the gene variation has effects on the fat cells on women’s abdomens and hips, causing the cells to become larger. It is active only in fat tissue and no other tissue when it comes to its effect on Type 2 diabetes. The defect in the creation of the fat cells means that the women’s bodies are more likely to have problems using blood sugar.
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