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Ovarian cancer is the deadliest form of cancer of the reproductive system, but treatment is effective if the cancer is discovered early. Cell culture experiments showed that a complex interplay between healthy and cancer cells facilitate the spread of cancer.
Normally, the peritoneal cavity is lined with so-called mesothelial cells, which form the mesothelium- a slippery, non-sticky surface layer that lines the body’s cavities and internal organs, protecting them. But in ovarian cancer, the new study revealed, macrophages transform these mesothelial cells into sticky cells that help cancer cells to attach.
The interactions between the normal cells in human body can influence metastasis, further experiments with mice confirmed the results. The researchers examined human samples and found that people with ovarian cancer indeed had increased levels of MIP-1β and P-selectin.
An HIV drug- Maraviroc is known to block MIP-1β receptors, and two drugs for various blood disorders which are still being trialed inhibit P-selectin.
haleplushearty.org