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According to a new study in PLOS Medicine by Ingvild Vik and colleagues from the University of Oslo, Norway, using Ibuprofen for treating antibiotics in women with uncomplicated urinary tract infection, (cystitis), leads to longer duration of symptoms and more serious adverse events related to the spread of the primary infection.
Some women will experience an uncomplicated urinary tract infection which can resolve without further complications. A short course of antibiotics is a widely accepted standard for the treatment of bacterial urinary tract infection, but antibiotic resistance is a growing serious public health problem. Some prior studies have suggested that treatment with non-steroidal anti-inflammatory drugs likl ibuprofen may support recovery of a urinary tract infection, raising the possibility that antibiotic use could be reduced.
In the current study, the authors randomized different women from Scandinavian countries with uncomplicated urinary tract infections to received either standard treatment of antibiotics for 3 days, or ibuprofen as a symptomatic treatment without an antimicrobial effect. Women’s symptoms, bacterial growth from urinary samples, and the occurrence of adverse events including systemic infection or hospitalization were monitored during the study.
This shows that women that used ibuprofen without antibiotics took three days longer to get well compared to those that used antibiotics. Women that used Ibuprofen developed a febrile urinary tract infection and serious kidney infection which did not occur in those that used antibiotics. The research shows that it is not safe to recommend ibuprofen instead of antibiotics in uncomplicated cystitis, due to the increased risk of developing a serious upper urinary tract infection.
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