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Mosquito saliva contains hundreds of proteins, researchers have discovered that the interaction of these proteins with the human immune system causes an immune response that can be detected for days after a mosquito bite. Common mosquito-transmitted diseases are; malaria, dengue, West Nile, Zika, and chikungunya fever.
Previous studies have shown that properties of a mosquito bite-including mosquito saliva-exacerbate some of these diseases; in mice, infections caused by a mosquito bite are often more severe than those caused by needle injection of the parasite. Researchers studied the effect of mosquito bites on human immune cells in mice engrafted with human hematopoietic stem cells-leading the animals to have components of a human immune system.
They studied small changes in the levels and functions of these immune cells after each mouse was bitten by four mosquitoes on their footpads. After getting bitten by mosquitoes uninfected with any pathogen, the humanized mice showed multiple types of human immune responses, with altered Th1 and Th2 T helper cells and an increase in the levels of cytokines.
At various points during the immune responses, there were also increases to levels of natural killer T cells, natural killer cells , CD8+ T cells , mononocytes, and macrophages. Overall, evidence of the immune responses lasted up to 7 days post-bite and were seen in multiple tissue types, including the blood, skin and bone marrow. Knowing the effects of mosquito saliva could provide the treatments
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