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According to the university of Michigan study, polygenic risk scores could be useful to stratify the risk of several cancers among patients. researchers at U-M’s School of Public Health conducted a phenome-wide association study in 28,260 unrelated, genotyped patients of recent European ancestry to evaluate whether polygenic risk scores for common cancers are associated with multiple phenotypes.
The study used data from participants’ electronic health records, the results demonstrate that polygenic risk scores, a summary score constructed based on results obtained from large population-based genome-wide association studies, can be potentially useful for cancer risk stratification among patients in an academic medical center.
Looking at the data, it was surprising to see how logical the secondary diagnosis associations with the risk score were. The association plots of the risk scores against the phenome can make diagnosis easy. A
polygenic risk score for squamous cell carcinoma-a common skin cancer form showed a strong association for various forms of skin cancer, but also with actinic keratosis, a potentially precancerous skin lesion.
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