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Complicated urinary tract infection cUTI is a UTI occurring in a patient with an underlying complicating factor of the genitourinary tract, such as a structural or functional abnormality. Patients with pyelonephritis, regardless of underlying abnormalities of the urinary tract, are considered a subset of patients with cUTI
Zemdri is an aminoglycoside with once-daily dosing that has activity against certain Enterobacteriaceae, including CRE and ESBL- producing Enterobacteriaceae. Zemdri (plazomicin) for adults with complicated urinary tract infections (cUTI), including pyelonephritis, caused by certain Enterobacteriaceae in patients who have limited or no alternative treatment options.
Zemdri is an intravenous infusion, administered once daily. The most common side effects of patients treated with Zemdri were decreased kidney function, diarrhea, hypertension, headache, nausea, vomiting, and hypotension.
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