Genetic risk of heart failure

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Heart failure is common in spome families but it is unknown whether this familial transition is caused by genetic or lifestyle factors. Studying adoptees in relation to both their biological parents and adoptive parents, a new population study in Sweden has found that genetic heritage is the dominant factor when it comes to heart failure in these families.

The results of the study do not mean that a person’s lifestyle is insignificant to their risk of heart failure, but they indicate that hereditary factors are less than 26 per cent of all cases of heart failure. Research studied Swedish-born adoptees, whom they linked to their biological parents and their adoptive parents through the Swedish multigenerational register.

A total of 21 643 adoptees, all born between 1942 and 1990, were tracked, along with their parents, between 1964 and 2015 with regard to the incidence of heart failure as recorded in hospital registers in the Swedish National Patient Register. The study found the risk of heart failure in adoptees who had at least one biological parent with heart failure to be 45 per cent higher than in a control group with no biological parent suffering from heart failure.

On the other hand, there was no increased risk in individuals with adoptive parents with heart failure, compared with the control group. Heart failure often depends on a combination of several risk factors, the occurrence of heart failure in a biological parent is a risk factor for heart failure.

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