Instead of surgery, doctors treat recurrent or inoperable tumors with chemotherapy or a heat therapy known as laser interstitial thermal therapy (LITT). Neurosurgeons drill a tiny hole in the skull and insert a laser, guiding it through the brain to the tumor on a path designed to cause the least damage. The laser emits pulses of heat that kill the surrounding tumor cells in the brain.
Patients with recurrent disease lived an average of eleven months after receiving laser therapy. Other studies have found that treatment with the chemotherapy drugs bevacizumab or temozolomide typically extends glioblastoma patients about nine months.