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Losing a single night’s sleep may affect the liver’s ability to produce glucose and process insulin, increasing the risk of metabolic diseases such as hepatic steatosis -fatty liver and type 2 diabetes. Sleep deprivation has been associated with eating more, moving less and having a higher risk of developing type 2 diabetes.
According to researchers from Toho University Graduate School of Medicine in Japan, it was not clear whether glucose intolerance was due to the changes in food intake or energy expenditure or to the sleep deprivation. The researchers studied two groups of mice: One group was kept awake for six hours each night while the control group was allowed to sleep as desired.
The research team offered unlimited high-fat food and sugar water mimicking lifestyle-related food choices to both groups prior to the study. During the sleep/wake period, the animals had limited opportunity for physical activity. They measured glucose levels and fat content of the liver immediately after the trial period.
Blood glucose levels were significantly higher in the sleep deprived group than controls after one six-hour session of wakefulness. Triglyceride (fat) levels and the production of glucose in the liver also increased in the sleep deprivation group after a single wake period. Elevated liver triglycerides are associated with insulin resistance, or the inability of the body to process insulin properly. Lack of sleep changed the expression of enzymes that regulate metabolism in the liver in the sleep deprived group.