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According to the University of California, people whose fat builds up around abdomen have a higher risk of brain inflammation while pear shapes-whose weight gathers on hips, thighs or buttocks, have a lower risk. Obese male mice who store fat on their fronts, have more inflammation than their ‘pear’ female counterparts.
The researchers analysed three-week-old male mice. Like men, male rodents tend to store fat around their abdomens, creating an apple shape. They also looked at female mice, who typically deposit fat around their hips, like women. Some of the animals were fed a high-fat diet while others had a standard eating regimen. Blood samples were collected from all the mice to determine how their diets affected their hormone levels.
Results suggest obese male rats store fat on their abdomens, creating an apple shape. The rodents also have higher levels of inflammation in their brains. Obese female rats, however, store excess fat beneath their skin and have lower amounts of inflammation. Abdominal fat is fat around visceral organs gets more inflamed with a fat overburden.
The brain has been considered an “immune protected site”, but we show that peripheral inflammation “spills over” into the brain, which, in turn, may cause neuronal problems. Long term brain inflammation has previously been associated with damage to the organ. Obese male mice are also more likely to develop metabolic syndrome than their female counterparts.
Metabolic syndrome occurs when a person has at least three of the following: abdominal obesity, high blood pressure, elevated blood sugar, high amounts of fat in their blood and high cholesterol. Mice on high-fat diet develop metabolic syndrome-a constellation of pathologies that includes type 2 diabetes and insulin insensitivity-similarly to obese humans. Obese men have lower testosterone levels, contributing to low libido, low energy, and reduced muscle strength.