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It is possible to reduce damaged cells and extend lifespan and improve health, even when treatment was initiated late. Treatment of aged mice with fisetin, found in many fruits and vegetables has significant positive effects on health and lifespan. As people age, they accumulate damaged cells. When the cells get to a certain level of damage they go through an aging process- cellular senescence. The cells also release inflammatory factors that tell the immune system to clear those damaged cells.
Immune system of a child is healthy and is able to clear the damaged cells. But as people age, they aren’t cleared as effectively. Thus they begin to accumulate, cause low level inflammation and release enzymes that can degrade the tissue.
A natural product-fisetin, reduces the level of damaged cells in the body. Researchers treated mice towards the end of life with this compound and see improvement in health and lifespan. Fisetin is a senotherapeutic that extends health and lifespan.
Fisetin is a plant polyphenol from the flavonoid group. It can be found in many plants, where it serves as a colouring agent. It is also found in many fruits and vegetables like strawberries, apples, persimmons, onions and cucumbers.