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Bacteria that causes stomach cancer increase the risk of colon cancer. Researchers analyzed data from more than 4,000 colon or rectal cancer cases in the United States. They found a significant association between rates of these cancers and infection with a virulent strain of H. pylori bacteria that’s especially common among black Americans.
The researchers found that antibodies indicating H. pylori infection were equally common in colorectal cancer patients and people without the cancer-four in 10 patients tested positive. White patients had below average H pylori infection rates, Asian Americans had average rates, while blacks and Hispanics had high rates. Among blacks, rates were 71 percent among colorectal cancer patients and 65 percent among non-cancer patients. Among Hispanics, rates were 74 percent among the cancer patients and 77 percent among those without cancer.
Looking at antibodies to four H. pylori proteins, the researchers found one protein in particular, VacA, was most strongly linked with increased risk of colorectal cancer in black Americans. High levels of antibodies to this protein were associated with colorectal cancer rates in blacks and Asian Americans. VacA antibodies increase the odds of colorectal cancer in African Americans and Asian Americans, and not in whites and Latinos.