Yupelri for treating chronic obstructive pulmonary disease COPD

Yupelri is a prescription medicine used to treat chronic obstructive pulmonary disease (COPD). COPD is a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both.

Yupelri is an anticholinergic medicine. Anticholinergic medicines help the muscles around the airways in your lungs stay relaxed to prevent symptoms such as wheezing, cough, chest tightness, and shortness of breath.

Yupelri is used long-term. One vial of Yupelri is inhaled through your nebulizer one time each day to improve symptoms of COPD for better breathing.

Yupelri is not used to relieve sudden breathing problems and will not replace an inhaled rescue medicine. This medicine should not be used in children. It is not known if this medicine is safe and effective in children.

Before using the medicine, tell your healthcare provider about all your medical conditions, including if you:

• have eye problems such as glaucoma.
• have prostate or bladder problems, or problems passing urine.
• have liver problems.
• are allergic to any of the ingredients in Yupelri or any other medicines. See the end of this page for a complete list of ingredients.
• are pregnant or plan to become pregnant. It is not known if this medicine may harm your unborn baby.
• are breastfeeding. It is not known if this medicine passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Yupelri and certain other medicines may interact with each other. This may cause serious side effects.

Especially tell your healthcare provider if you take:

• other anticholinergic medicines (including tiotropium, ipratropium, aclidinium, umeclidinium, glycopyrrolate)
• atropine

• Yupelri is only for use with a nebulizer.
• Do not use Yupelri unless your healthcare provider has taught you how to use it with your nebulizer and you understand how to use it correctly.
• Use this medicine exactly as your healthcare provider tells you to use it. Do not use it more often than prescribed.
• Yupelri is taken as a breathing treatment (by oral inhalation) and should be used with a standard jet nebulizer with a mouthpiece connected to an air compressor.
• Do not mix Yupelri with other medicines in your nebulizer.
• Use one vial of Yupelri, one time each day. Do not use more than one vial per day.
• If you use too much, call your healthcare provider or go to the nearest hospital emergency room right away if you have any unusual symptoms, such as worsening shortness of breath, chest pain, or increased heart rate.
• Do not use other medicines that contain an anticholinergic for any reason. Ask your healthcare provider or pharmacist if any of your other medicines are anticholinergic medicines.
• Yupelri does not relieve sudden symptoms of COPD and you should not use extra doses of Yupelri to relieve these sudden symptoms. Always have an inhaled rescue medicine with you to treat sudden symptoms. If you do not have an inhaled rescue medicine, call your healthcare provider to have one prescribed for you.
• Do not stop using this medicine, even if you are feeling better, unless your healthcare provider tells you to because your symptoms might get worse.
• Call your healthcare provider or get emergency medical care right away if:
  • your breathing problems get worse.
  • you need to use your inhaled rescue medicine more often than usual.
  • your inhaled rescue medicine does not relieve your symptoms.

Yupelri can cause serious side effects, including:

• Sudden breathing problems immediately after inhaling your medicine.
• New or worsened eye problems including acute narrow-angle glaucoma.
• Acute narrow-angle glaucoma can cause permanent loss of vision if not treated. Symptoms of acute narrow-angle glaucoma may include:
  • red eyes
  • blurred vision
  • seeing halos or bright colors around lights
  • eye pain or discomfort
  • nausea or vomiting

  If you have any of these symptoms, call your healthcare provider right away before using another dose.

• Urinary retention. People who use Yupelri may develop new or worse urinary retention. Symptoms of urinary retention may include:
  • difficulty urinating
  • urinating frequently
  • urination in a weak stream or drips
  • painful urination

  If you have any of these symptoms, call your healthcare provider right away before using another dose.

• Serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction:
  • rash
  • hives
  • severe itching
  • swelling of your face, mouth, and tongue
  • difficulty breathing or swallowing

Common side effects include:

• cough
• runny nose
• upper respiratory tract infection
• headache
• back pain

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