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The approach, called Karyomapping, was originally designed to detect and screen for single gene and chromosome disorders simultaneously in human IVF embryos.
Now the application of the same technique to cattle IVF – involving screening at the embryo stage rather than when a calf is born – will allow decisions on best quality genetic stock to be made earlier.
The latest research, led by Professor Darren Griffin of the University’s School of Biosciences, will allow for better quality genetics to be introduced more rapidly into the breeding herd.
Moving genetically screened embryos around the country, and around the world, rather than live animals, is also more biosecure, environmentally friendly and means that they can be delivered to breeding farms in a more efficient manner.
Professor Griffin said: ‘In-vitro produced embryos are used widely in the cattle breeding industry but this is the first time they have undergone a whole genomic screen beforehand. We have used Karyomapping to screen for genetic merit, as well as the incidence of chromosome disorders, which could significantly reduce the chances of the embryos developing into live-born calves.’
The researchers report the birth of the calves to be born following use of the technique, including the first named Crossfell Cinder Candy, born on a farm near Penrith.
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The study, entiled Karyomapping for simultaneous genomic evaluation and aneuploidy screening of preimplantation bovine embryos: The first live-born calves also involved Dr Kara Turner and Dr Giuseppe Silvestri at the University of Kent, working in collaboration with a team from the University of Nottingham and the Paragon Veterinary group in Cumbria. See: https://doi.org/10.1016/j.theriogenology.2018.11.014
For more information or interview requests contact Martin Herrema at the University of Kent Press Office.
Tel: 01227 816768
Email: M.J.Herrema@kent.ac.uk
News releases can also be found at http://www.kent.ac.uk/news
University of Kent on Twitter: http://twitter.com/UniKent
Notes to editors
1.
The original Karyomapping research, announced in the paper Karyomapping: a novel molecular karyotyping method based on mapping crossovers between parental haplotypes with broad applications for preimplantation genetic diagnosis of inherited disease, was carried out by a University of Kent-related team, including Professor Griffin and Professor Alan Handyside. It was published in the Journal of Medical Genetics.
2.
Established in 1965, the University of Kent – the UK’s European university – now has almost 20,000 students across campuses or study centres at Canterbury, Medway, Tonbridge, Brussels, Paris, Athens and Rome.
It has been ranked 22nd in the Guardian University Guide 2018 and in June 2017 was awarded a gold rating, the highest, in the UK Government’s Teaching Excellence Framework (TEF).
In the Times Higher Education (THE) World University Rankings 2015-16, it is in the top 10% of the world’s leading universities for international outlook and 66th in its table of the most international universities in the world. The THE also ranked the University as 20th in its ‘Table of Tables’ 2016.
Kent is ranked 17th in the UK for research intensity (REF 2014). It has world-leading research in all subjects and 97% of its research is deemed by the REF to be of international quality.
In the National Student Survey 2016, Kent achieved the fourth highest score for overall student satisfaction, out of all publicly funded, multi-faculty universities.
Along with the universities of East Anglia and Essex, Kent is a member of the Eastern Arc Research Consortium.
The University is worth £0.7 billion to the economy of the south east and supports more than 7,800 jobs in the region. Student off-campus spend contributes £293.3m and 2,532 full-time-equivalent jobs to those totals.
Kent has received two Queen’s Anniversary prizes for Higher and Further Education.
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