Why painkillers may increase the pain

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Around eight million people in the UK live with chronic pain, where symptoms persist for longer than three months.

Diagnosis of chronic pain often leads to a separate set of problems entirely due to the painkilling medication they are prescribed that makes the users dependent on the drugs.

A growing concern is that many more people are now being prescribed opioid painkillers, which have their unique set of problems. Opioids are known to be highly addictive. However the belief has been that this is not the case when patients are in genuine pain; that it’s safe to prescribe increasing doses to treat it.

Yet this belief is mistaken, say experts, and lies at the heart of the epidemic of opioid addiction currently causing turmoil in the U.S., where two million Americans are now addicts, with 115 deaths a day from opioid overdose. Now a leading expert is warning the UK could face its own version of the devastating U.S. problem.

Professor Jane Ballantyne, a pain management expert, was one of the first clinicians, back in 2003, to warn of the ‘societal catastrophe’ now facing the U.S.
Since then, she has warned persistently of the health risks of so-called ‘open-ended dose escalation.

Professor Ballantyne, who trained at the Royal Free Hospital in London and is now a professor of anaesthesia and pain management at the University of Washington in the U.S., has not made herself popular with her message.
In 2015, she caused outrage among fellow pain specialists by insisting that ‘reducing pain intensity should not be the goal of doctors who treat chronic pain’ because chronic pain causes changes in the brain that mean painkillers won’t work.

The result is that people suffer ever higher levels of pain despite being on high levels of opioids and they interpret that as meaning they need more of the same,’ says Professor Ballantyne.
A further cause for concern is the growing evidence that people who are most susceptible to chronic pain are also most at risk of opioid addiction. Yet the NHS remains largely oblivious to what is now a clear and present danger.

We know that people with chronic pain are at a greater risk of running into problems with dependency, yet there’s often very little training for GPs to raise awareness of these issues,’ says Roger Knaggs, an associate professor in clinical pharmacy practice at the University of Nottingham.

This is despite ‘substantial evidence showing that opioids cause real harm to the vast majority of chronic pain sufferers while offering no benefit,’ says Professor Knaggs, who is also honorary secretary of the British Pain Society.

We’re brought up to believe that if you are sore, your GP will give you a pill for it and that it will work. My doctor seemed to believe that as much as I did,’ recalls Amanda.The practice is for people to be discharged as early as possible, often while they are still suffering post-surgical pain,’ explains Professor Knaggs. ‘So they are sent home with opioids, often oral morphine. ‘Yet the patient’s discharge letter may not mention that this is for short-term use, and GPs may provide repeat prescriptions until it becomes difficult for patients to stop.’


There are now services for people with chronic pain, such as NHS Pain Management Programmes, run by multi-disciplinary teams including psychologists and physiotherapists, that aim to help them come to terms with it.The fact is chronic pain is a lifestyle issue not a medical issue,’ adds Professor Ballantyne.
‘We know that acupuncture, yoga, tai chi and walking can relieve chronic pain by boosting the body’s natural opioid system. It’s a lesson we need to learn, though it might take generations to be widely accepted,’ she says.

However this won’t help people whose lives are already devastated by dependency on prescription opioids or ‘the growing number of patients being prescribed these drugs by their GPs and who are not being regularly reviewed’, says Sam Ahmedzai, a professor of palliative medicine at the University of Sheffield.

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