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Scientists have discovered a drug cocktail that clears senescent – or ‘zombie’ – cells from the body. Senescent cells are alive but non-functioning and have been linked to everything from arthritis to Alzheimer’s. They are also thought to cause the deadly lung disease idiopathic pulmonary fibrosis (IPF) by triggering inflammation.
Researchers gave patients the cancer drug Sprycel (dasatinib) and the plant supplement quercetin – found in red wine, onions and green tea – to test how zombie cells affect IPF. Patients taking the cocktail – both of which are known to trigger suicide in senescent cells – became significantly more mobile after just three weeks.
The findings raise hope that senolytic drugs may lead to a new way of targeting age-related disease. There are at least 20 serious conditions that senescent cells.
Obstructive IPF is a chronic lung disease that is ‘generally relentlessly progressive and fatal. IPF causes scarring of the lungs, which makes them less able to inflate and take in oxygen.
Obstructive IPF is a chronic lung disease that is ‘generally relentlessly progressive and fatal. IPF causes scarring of the lungs, which makes them less able to inflate and take in oxygen.
This has helped prevent a range of diseases in rodents, including osteoporosis and fatty liver.
In the first study of its kind, 14 elderly adults with controlled IPF were given dasatinib and quercetin over three consecutive days once a week for three weeksAnti-ageing drug derived from a compound in green tea, onions and red wine is on the horizon.
In the first study of its kind, 14 elderly adults with controlled IPF were given dasatinib and quercetin over three consecutive days once a week for three weeksAnti-ageing drug derived from a compound in green tea, onions and red wine is on the horizon.
The findings raise hope that senolytic drugs may lead to a new way of targeting age-related disease. Drug cocktail that clears ‘zombie cells’ from the body may target ageing.
Senescent cells have been shown to accumulate in the brains of people carrying dangerous amounts of weight.
To test a long-held theory they may affect mental health, researchers from the Mayo Clinic and Newcastle University gave obese mice a cocktail of dasatinib and quercetin.
Senescent cells have been shown to accumulate in the brains of people carrying dangerous amounts of weight.
To test a long-held theory they may affect mental health, researchers from the Mayo Clinic and Newcastle University gave obese mice a cocktail of dasatinib and quercetin.
After two months, the senescent cells in the rodents’ brains had cleared and been replaced with healthy tissue, with the animals also showing reduced signs of anxiety. The researchers hope these medications may lead to a new way of treating obese anxiety sufferers.
Blood samples were taken to measure senescence biomarkers. IPF severity was also assessed via lung function tests and the results of a six minute walking distance test, which investigates the area a patient can cover, and the number of rests they require, in that timeframe.
Results revealed taking dasatinib and quercetin significantly improved the participants’ performance on the walk test, with them being able to cover an extra 21metres in six minutes.
They could also get up from a chair two seconds faster. ‘This is a glimmer it might actually work,’ Dr Kirkland said. ‘The results were impressive. All 14 got better in their functional ability.’
They could also get up from a chair two seconds faster. ‘This is a glimmer it might actually work,’ Dr Kirkland said. ‘The results were impressive. All 14 got better in their functional ability.’
But the drug combination had no impact on the participants’ lung function.
The researchers claim the study intended to show ‘feasibility rather than drug efficacy’, with its number of participants being too small to evaluate changes to the level of senescent cell biomarkers.
They add, however, certain biomarkers showed ‘potential for reduction’, with at least eight participants having decreased circulating levels. The levels even started to go down after just half-an-hour.
The researchers claim the study intended to show ‘feasibility rather than drug efficacy’, with its number of participants being too small to evaluate changes to the level of senescent cell biomarkers.
They add, however, certain biomarkers showed ‘potential for reduction’, with at least eight participants having decreased circulating levels. The levels even started to go down after just half-an-hour.
‘It has a hit-and-run effect,’ Dr Kirkland said. ‘The drug starts working quickly and we would ideally like to be able to give it just once a month.’ The treatment was generally found to be safe with side effects typically being limited to just cough, shortness of breath and skin irritation.
However, one patient had to be hospitalised with suspected pneumonia and fluid on the lungs, while others experienced severe headache.
The researchers therefore stress further studies are required before senolytic drugs should be used for IPF. This is simply the start of human studies,’ Dr Kirkland said. ‘We don’t know what lies ahead and full trials are now ongoing. So at the moment it’s baby steps, but those baby steps are moving quickly.’
Already approved senolytic medications include the plant supplement fisetin and the lymphoma drug navitoclax.
The researchers therefore stress further studies are required before senolytic drugs should be used for IPF. This is simply the start of human studies,’ Dr Kirkland said. ‘We don’t know what lies ahead and full trials are now ongoing. So at the moment it’s baby steps, but those baby steps are moving quickly.’
Already approved senolytic medications include the plant supplement fisetin and the lymphoma drug navitoclax.