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HPV vaccination programs significantly reduce human papillomavirus infections and precancerous cervical lesions, a new global review finds. Vaccination protects against the HPV strains that cause the majority of cervical cancers.
Researchers analyzed 65 studies that included data collected over eight years from more than 60 million people in 14 high-income countries. They found a significant decline after vaccination in the two types of HPV that cause 70% of cervical cancers — HPV 16 and 18.
In addition, they reported an 83% decrease among 13- to 19-year-old girls and and a 66% decrease among women in their early 20s five to eight years after vaccination. There was a 54% reduction in three other types of HPV — 31, 33 and 45 — in teen girls.
Researchers also found significant decreases in precancerous cervical lesions, with a 51% reduction in 15- to 19-year-olds and a 31% reduction in 20- to 24-year-old. There were far fewer cases of genital warts, as well. Cases decreased 67% among 15- to 19-year-old girls and 48% in boys; 54% in 20- to 24-year-old women and 32% in men; and 31% in 25- to 29-year-old women.