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Some ovarian cancers start in the fallopian tubes. Ovarian cancer cells have more in common with cells covering the tips of fallopian tubes than with those on the surface of ovaries. If biomarkers can be found for these tubal cells, direct tests on tubal tissue might be able to detect ovarian cancer.
The research team plans to conduct studies that will seek to apply the current molecular biology findings to clinical practice, removing a woman’s fallopian tubes, but not her ovaries, may reduce the risk of ovarian cancer in those at high risk.
The current study confirm previous results that had suggested that many high-grade serious cancers in the pelvis are preceded by abnormal cells- lesions occurring in the fallopian tubes, called serous tubal intraepithelial carcinoma STIC.
Past studies in several cancer types had shown that cancer cells with different origins have different genetic profiles. Cancer cells may arise from clisertissue or may have spread to a location from another part of the body, but their genetic profile reflects the tissue of origin.
If STIC cells and ovarian cancer cells had different genetic profiles, they must have originated in different tissue types. Instead, in-depth molecular analyses of cells from different women with high-grade serous carcinoma failed to identify any genetic differences between cancer cells arising in the tubes and serous ovarian cancers occurring elsewhere in the pelvis.
Ovarian cancer is more aggressive than many other cancers because it is hard to diagnose in its earliest stage. Fewer than 50 percent of women diagnosed with the disease survive for longer than five years after their diagnoses.
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