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A study of mice exposed to e-cigarettes shows that it may lead to accumulation of fat in the liver. E-cigarettes contain nicotine which is associated with non-alcohol fatty liver diseases. In the 12-week study, researchers studied mice missing the gene for apolipoprotein E, which makes them prone to developing heart disease and fat in the liver.
Mice were fed a diet high in fat and cholesterol. One group of mice was exposed to e-cigarette aerosol, so that their blood nicotine levels were similar to e-cigarette users. A second group of mice were exposed to saline aerosol. The researchers collected liver samples, and looked at genes in the liver affected by e-cigarettes using RNA sequence analysis.
They found changes in genes that were associated with fatty liver development and progression in the mice exposed to e-cigarettes. They also discovered that genes related to circadian rhythms were changed in mice exposed to e-cigarettes. Circadian rhythm dysfunction accelerates the development of liver disease including fatty liver diseases.
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