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According to Penn State College of Medicine researchers, animals on sulfur amino acid-restricted diets showed high levels of sound health and longevity, this could also have positive impacts on people. Amino acids are the building blocks of all proteins in the body. A subcategory called sulfur amino acids includes methionine (Met) and cysteine (Cys), which not only make up proteins but also play many roles in metabolism and health.
In the 1990s, studies show health benefits in animals fed Met-restricted diets. In one early study involving rats, 80 percent Met restriction increased average and maximum lifespans by between 42 and 44 percent. Animals on calorie-restricted diets live longer and healthier. In a study led by Zhen Dong, sulfur amino acid restriction consistently demonstrated a range of beneficial effects including enhanced lifespan without calorie restriction.
Met restriction has been associated with delayed aging and longer lifespans in human cells, yeast and animals including fruit flies and rodents. Animals fed sulfur amino acid-restricted diets also had health improvements including reductions in body weight, fat and oxidative stress; fewer cancerous tumors; enhanced insulin sensitivity; and more efficient fuel-burning.
Sulfur amino acids are important for growth. One of the effects of their restriction is to inhibit growth, leading to healthier, longer-lived but smaller animals. When sulfur amino acid restriction was initiated in fully grown adult animals, circumventing the problem seen in younger animals.Those results we think are important because they indicate that if we were to initiate a restricted diet in adult human beings, we would still get the beneficial effects without growth retardation.
Studies involving people have associated sulfur amino acids with increased body weight, metabolic syndrome, cardiovascular disease and cancer, suggesting that restricting Met and Cys could protect against these conditions. Many vegetarian diets are low in Met and Cys. Beans and other legumes are a good source of protein that are low in sulfur amino acids.
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