Effects of weight loss surgery on bone

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Weight loss surgery can cause declines in bone mass and strength, and it is linked with an increased risk of bone fractures. Skeletal changes after surgery appear early and continue even after weight loss plateaus and weight stabilizes. Nutritional factors, mechanical unloading, hormonal factors, and changes in body composition and bone marrow fat may contribute to poor bone health.

Studies have examined the effects of the Roux-en-Y gastric bypass procedure, which was the most commonly performed weight loss procedure worldwide until it was very recently overtaken by sleeve gastrectomy. Because sleeve gastrectomy is a newer procedure, its skeletal effects have not yet been well defined.

The findings indicate clinical guidelines on weight loss surgery should consider bone health as a priority. “Current clinical guidelines do address bone health, but most recommendations are based on low-quality evidence or expert opinion,” said co-author Dr. Anne Schafer, of the University of California, San Francisco and the San Francisco VA Health Care System.

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