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A new study from University of Minnesota Medical School researchers has demonstrated that psychosocial stress can shorten the lifespan in mice. Stress and socio-economic status has been connected to morbidity and mortality in humans.
According to a new publication in Aging Cell, Bartolomucci and fellow researchers identified that lifelong social stress lead to a shortened lifespan and increased the risk of
cardiovascular disease in mice.
Cellular senescence mechanisms and diseases associated with aging, such as atherosclerosis which is essentially the narrowing and clogging of arteries due to fat deposits.
Beyond shortening of life span, the team observed an earlier onset of organ lesions and tumors, an associated rise in markers of senescent cells, which often coincide with age-related pathologies, and spontaneous onset of early-stage atherosclerosis, an unprecedented finding in a species where this cardiovascular disease usually develops in genetically susceptible individuals fed diets rich in lipids.
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