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Link between alcoholism and depression

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Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. It affects how feeling, thinking and behavior and can lead to different emotional and physical problems.
Common symptoms are: feelings of sadness, loss of interest, sleep disturbances, weakness, anxiety and suicidal thoughts. Depression is common among people struggling with alcohol use disorders.
 Purdue University researchers have developed a technology that may treat  alcohol use disorder by reducing  alcohol intake while also having the potential to treat depression.
Researchers focused on a G protein-coupled receptor-the delta opioid receptor, which is a novel drug target that is different from the receptor in the body that binds prescription opioids. They developed drugs that bind to this new target and selectively activate a particular protein-signaling cascade of this receptor.
This property of the drug  can be used to provide a therapeutic effect and avoid a side effect. Current types of delta opioids have been failing in clinical trials because they activate multiple cascades, including those associated with increased side effects like seizures.

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The Purdue drug has proven effective in preclinical tests in reducing alcohol use and has pharmacological properties that should enable it to reduce depression without inducing seizures.

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